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KMID : 0368820050440060655
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 6 p.655 ~ p.662
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Association of Dopamine D4 Receptor Gene(DRD4) VNTR Polymorphism and Response to Methylphenidate Treatment in Korean ADHD Children.
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Chun Keun-Ah
Hwang Jun-Won
Shin Min-Sup
Hong Kang-E
Kim Bung-Nyun
Cho Soo-Churl
Kim Jae-Won
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Abstract
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Objectives: In the present study, we investigate the association between homozygosity of the 4-repeat allele (4/4) at the DRD4 and the response to the treatment with MPH in Korean children with ADHD.
Methods: The present study included 71 children with ADHD (8.231.78 years) from two children’s psychiatric clinics in South Korea. All drug-naive children with ADHD were treated with MPH for about 8 weeks. The subjects who showed improvement of over 50% compared with the baseline ARS score after 8 weeks of treatment were termed as the ’good response’ group. The subjects who showed an improvement of less than 50% were considered as the ’poor response’ group. After genotyping for DRD4 were performed, we investigated correlation between homozygosity for 4-repeat allele at DRD4 and the response to MPH treatment.
Results: We found that while 79.5% (31/39) of the subjects with homozygosity of 4-repeat allele at DRD4 showed good response to MPH treatment, 68.8% (22/32) of the subjects without homozygosity of 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their parents (chi2=16.762, df=1, p<0.01). We also found that while 61.5% (24/39) of the subjects with homozygosity of4-repeat allele at DRD4 showed good response to MPH treatment, 87.5% (28/32) of the subjects without homozygosity of the 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their teachers (chi2=17.698, df=1, p<0.01).
Conclusion: Our findings support an association between the homozygosity of 4-repeat allele and a good response to MPH in ADHD of Koreans.
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KEYWORD
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ADHD, 4-repeat allele, DRD4 VNTR, Methylphenidate, Treatment response
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